Antidiuretic hormone, also known as vasopressin, is a hormone released from the posterior pituitary gland. It is important primarily for its effects on the kidneys, where it increases water reabsorption. Vasopressin is also a powerful vasoconstrictor. It acts through two receptors, V1 and V2. Fluid retention is mediated by V2 receptors and occurs at low plasma concentrations of vasopressin due to activation of adenylate cyclase and increased production in the nephron collecting duct. It increases the permeability of the membrane to water. Vasopressin causes smooth muscle contraction primarily in the cardiovascular system. Vasoconstriction occurs through the mediation of V1 receptors and requires higher concentrations of vasopressin. Antidiuretic hormones are made by special nerve cells in the area of the base of the brain known as the hypothalamus. Nerve cells transport hormones through nerve fibers (axons) to the posterior pituitary gland, where they are released into the bloodstream. Antidiuretic hormones help control blood pressure by acting on the kidneys and blood vessels. Its main role is to maintain the body's water content by reducing the amount of water excreted in the urine. It does this by returning the water in the urine to the body in certain areas of the kidneys. As a result, more water returns to the bloodstream, increasing urinary levels and reducing water loss. Higher levels of antidiuretic hormone narrow (narrow) blood vessels and increase blood pressure. Fluid deficiency (dehydration) can only be ultimately improved by increasing fluid intake. The release of antidiuretic hormone from the pituitary gland into the bloodstream is regulated by several factors. The decrease in blood volume and hypotension that occurs during dehydration and bleeding are detected by sensors (baroreceptors) in the heart and large blood vessels. These stimulate the release of antidiuretic hormones. Antidiuretic hormones are released when the salt concentration in the bloodstream increases. It is recognized by specialized nerve cells (osmoreceptors) in the hypothalamus that simulate the release of antidiuretic hormone from the pituitary gland. Antidiuretic hormones are also released during thirst, nausea, vomiting and pain, and help maintain fluid volume in the bloodstream during stress and injury. Alcohol prevents the release of antidiuretic hormones and increases urine production and dehydration. At high levels of antidiuretic hormone, the kidneys retain water in the body. There is a condition called inappropriate antidiuretic hormone secretion syndrome (SIADH; a type of hyponatremia) that releases excess antidiuretic hormone when it is not needed. The Journal of Bioequivalence & Bioavailability (JBB) is an academic journal that encompasses a wide range of current research on FDA Bioequivalence, Bioequivalence antipsychotics, Bioequivalence anticancers, Bioequivalence antidiuretics, Bioequivalence antipsychotics, BA/BE Studies, Biosimilars, Advances in Bioavailability and offers a promising platform for the authors to make their valuable contributions towards the journal. Visit: https://www.walshmedicalmedia.com/bioequivalence-bioavailability.html Submit Manuscript at: https://www.walshmedicalmedia.com/submissions/bioequivalence-bioavailability.html Instructions for Authors: https://www.walshmedicalmedia.com/bioequivalence-bioavailability/instructionsforauthors.html Journal Archive: https://www.walshmedicalmedia.com/bioequivalence-bioavailability/archive.html