COVID-19, the disease caused by coronavirus SARS-Cov-2, has infected over 4 million people in 212 countries, of whom at least 272,000 have died. The ongoing economic and social impact of the pandemic is staggering, but despite a daily flood of news on the disease, few laypeople know that paradoxically, COVID-19 mostly kills through an overreaction of the immune system, whose function is precisely to fight infections.

In this context, we will deal about the transmission mechanisms of COVID-19. The infusion of the virus inside the body causes the immune defenses to a "cytokine storm”, an over-activation of white blood cells, which release too-great amounts of cytokines into the blood. The cytokine storm ultimately causes high fever, excessive leakiness of blood vessels, blood clotting inside the body, extremely low blood pressure, lack of oxygen and excess acidity of the blood, and build-up of fluids in the lungs.

Most deaths due to COVID-19 are due to respiratory failure so non-invasive mechanical ventilation through a mask and the ventilation through a tube are the potential methods to replace lung function in order to prevent Multiple Organ Dysfunction Syndrome. SARS-Cov-2 also invades the intestines, where it causes inflammation and leakiness of the gut lining, allowing the opportunistic entry of other disease-causing microorganisms. The secondary infections are lethal causing the adverse effects.

Diagnostic Pathology: Open Access officially organizes a platform for the Health care professionals and distinguished researchers around the world to explore about the potential therapeutic applications and the defense mechanisms involved in the SARS-Cov-2.

Regards,

Matthew Richard
Diagnostic Pathology: Open Access
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E-mail id: diagnospathol@pathologyinsights.org