Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock

Research & Reviews: Journal of Hospital and Clinical Pharmacy (RROIJ Publishing) is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of  not only Hospital and Clinical pharmacy but also in aspects like Drugs & Drug information studies, General anaesthesia, Automatized anaesthesia, Paediatric Anaesthesia, Obstetric Anaesthesia, Neuroanesthesia, All kind of surgeries General medicine & Critical care medicine, Preoperative Evaluation & Postoperative effects, Pain management, Drug information studies, Clinical reviews, Pharmacy practices, Patient care & Counselling, Ischemia reperfusion, Clinical trials, Patient management, Patient care, Nursing, Disease and hospitalization, Trauma care, and Incentive care etc.  

It gives us great pleasure to announce the call for paper on the occasion of 10^th Anniversary of the Journal at special and hefty discount of up to 50% on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.

The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Research article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.

Title: “Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock”

Abstract: With the previous norepinephrine shortage, alternative agents were required to treat patients with septic shock. This retrospective study evaluated whether the shortage of norepinephrine had an adverse effect on patients admitted to the intensive care unit with a diagnosis of severe sepsis or septic shock. This was a retrospective chart review, which compared patients who received norepinephrine versus those who did not. Eligible patients were those ≥ years old who were admitted to an intensive care unit with a diagnosis of sepsis and were initiated on a vasopressor to maintain hemodynamic stability. The specific primary endpoint was whether using norepinephrine versus other vasopressors had an effect on ICU length of stay. Secondary outcomes included mortality, blood pressure, mean arterial pressure, development of renal insufficiency, and vasopressor requirements. There were 288 patients screened and 214 patients who met the inclusion criteria (norepinephrine group=106 and nonnorepinephrine group=108). After accounting for potential differences in disease severity (APACHE II score), age, weight and gender, there was no difference in ICU length of stay (p=0.4); however, the odds of survival were 5.9 (95% CI: 3.1 to 11.1) times higher for those in the non-norepinephrine group (p<0.0001). Based on this retrospective analysis, patients that did not receive norepinephrine had a similar ICU LOS but had a higher rate of survival. The norepinephrine shortage did not have an adverse effect on patient outcomes.

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John Robert

Editorial Assistant

Research & Reviews: Journal of Hospital and Clinical Pharmacy

Email: clinpharmacy@journaloa.org