In the previous press releases, we have discussed about the Spike protein and its importance. In this context, we will know how Spike protein allows coronaviruses to enter cells. Viruses such as the novel SARS-CoV-2 would never be able to interact with the cells of prospective hosts such as animals and humans and cause infection without the S protein, so it acts as a potential target for vaccine and antiviral research activities.

The S2 subunit should undergo two large conformational changes once the S1 subunit binds to the host cell receptors to complete the virus fusion to the cell membrane. The first conformation, otherwise referred to as prehairpin, includes the transformation of an unstructured linker to become helical within the S2 subunit. The second conformational change to occur involves the inversion of this subunit’s C-helix to the coil, resulting in the formation of a six-helix bundle. The fusion peptide is anchored to the membrane of the host cell once these conformations are completed to allow the virus to move closer towards the cell membrane and eventually deliver the nucleocapsid to the target cell.

Diagnostic Pathology: Open Access is collecting manuscripts all over the globe on COVID-19 to endorse the advancement of current knowledge pertaining to clinical studies and scientific investigations and foster discussion in all the relevant aspects of Pathology such as Immunopathology, Virtual Pathology, Tissue based Diagnosis, Immunohistochemistry, Diagnostic Pathology of Infectious Diseases.

We have also announced a Special Issue on “Therapeutic Applications in COVID-19” acknowledging the significance in the Global Scientific Community. The Special Issue is being edited by our honourable Executive Editorial Chair Person Dr. Maria Teresa Mascellino. The Submissions are Open!

Regards,

Matthew Richard
Diagnostic Pathology: Open Access
WhatsApp: +32-2-808-66-57
E-mail id: diagnospathol@pathologyinsights.org