The Journal of Clinical and Experimental Pathology (ISSN: 2161-0681) deals with research on infectious disorders associated with immune system and immunological disorders, infectious diseases, treatment of infectious diseases, infectious medicine, epidemiology, diagnostic tests of infectious diseases, infection control, pathophysiology, clinical pathology , preventive medicine. Clinical Pathology deals with patient care, diagnostic services, novel treatments and research on immune infections. 

In the previous press releases, we have discussed about the Spike protein and its importance. In this context, we will know how Spike protein allows coronaviruses to enter cells. Viruses such as the novel SARS-CoV-2 would never be able to interact with the cells of prospective hosts such as animals and humans and cause infection without the S protein, so it acts as a potential target for vaccine and antiviral research activities.

The S2 subunit should undergo two large conformational changes once the S1 subunit binds to the host cell receptors to complete the virus fusion to the cell membrane. The first conformation, otherwise referred to as prehairpin, includes the transformation of an unstructured linker to become helical within the S2 subunit. The second conformational change to occur involves the inversion of this subunit’s C-helix to the coil, resulting in the formation of a six-helix bundle. The fusion peptide is anchored to the membrane of the host cell once these conformations are completed to allow the virus to move closer towards the cell membrane and eventually deliver the nucleocapsid to the target cell.

Diagnostic Pathology: Open Access is collecting manuscripts all over the globe on COVID-19 to endorse the advancement of current knowledge pertaining to clinical studies and scientific investigations and foster discussion in all the relevant aspects of Pathology such as Immunopathology, Virtual Pathology, Tissue based Diagnosis, Immunohistochemistry, Diagnostic Pathology of Infectious Diseases.

On the occasion of its 10 years, Successful Journey, Journal of Clinical and Experimental Pathology decided to provide a partial waiver on its article processing charges to promote quality research from across the nations of the globe to encourage the latest research in the field of Infections, Diseases and Medicine. Journal of Clinical and Experimental Pathology also planning to release a special issue on its new approaches.

Regards,

Robert Solomon

Editorial office

Journal of Clinical and Experimental Pathology

E-mail: pathol@eclinicalsci.com

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