Today, nurses face with caring for Covid-19 patients, consider as a new occupational stressor in the nursing profession. Primary Study Objective To investigate the effect of Benson's relaxation technique (BRT) on occupational stress of nurses exposed to Covid-19 patients.Design The present study is a two-group clinical trial with parallel design.The samples were and randomly allocated into BRT and control groups based on the inclusion and exclusion criteria. Participants 70 nurses working in the intensive care unit (ICU) in the Covid-19 treatment center in Sabzevar, Iran Intervention: Intervention group were performed the BRT exercises twice a day for 1 month during 20 minutes each time. The data was collection through Osipow Occupational Stress Questionnaire. Primary Outcome Measures Occupational stress The mean occupational stress score in the BRT group immediately and after 1 week of intervention, was significantly lower than the control group (P = 0.001). The repeated measure analysis of variances test showed a significant difference in the mean occupational stress score in the 6 subscales after the intervention between the two groups (P < 0.05).